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Having a sore throat can be a symptom of many conditions, and many people wonder if their own sore throat might be a sign of something more serious than the common cold.Specifically, infectious mononucleosis ("mono") and infection with Streptococcus bacteria ("strep throat") are two conditions that both produce an extremely painful sore throat.The body's immune system produces antibodies to attack and help destroy invading viruses and bacteria.These specific EBV antibodies can be detected in the blood of people who have been infected with mono.Infectious mononucleosis, "mono," "kissing disease," and glandular fever are all terms popularly used for the very common infection typically caused by the Epstein-Barr virus (EBV), but other viruses can also cause the disease.This article focuses specifically on the Epstein-Barr virus as a cause of mono since this is the characteristic virus associated with the condition.The term infectious mononucleosis was first used in 1920 when an increased number of lymphocytes were found in the blood of a group of college students who had fever and symptoms of the condition.The EBV that causes mono is found throughout the world.

The disease was first described in 1889 and was referred to as "Drüsenfieber," or glandular fever.Research has shown that, depending on the method used to detect the virus, anywhere from 20%-80% of people who have had mononucleosis and have recovered will continue to secrete the EBV in their saliva for years due to periodic "reactivations" of the viral infection.Since healthy people without symptoms also secrete the virus during reactivation episodes throughout their lifetime, isolation of people infected with EBV is not necessary.Most people have been exposed to the virus as children, and as a result of the exposure, they have developed immunity to the virus.It is of note that most people who are exposed to the EBV don't ever develop mononucleosis.An enlarged liver and abnormalities in liver function tests (blood tests) may be detected (see Complications, below).